Secondary Appointments

Biomedical Engineering, General Medical Sciences (Oncology, Pediatrics)


  • B.S., Zhejiang University, China, 1986
  • M.S., University of Akron, Akron, OH, 1993
  • Ph.D., Case Western Reserve University, Cleveland, OH, 1997

Research Summary

My expertise is in molecular imaging with specialty in PET imaging with small molecule radio-tracers. I am also well-versed in quantitative analysis and can contribute to the processing of dynamically acquired PET image data for correlation with histological evaluation. Over the years, I have gain considerable experience in animal imaging using micro-scanners for small animal such as mice and rats, and clinical scanners for mid- and large size animals such as rabbits, woodchucks, canines, and pigs. Cancer imaging is the main research focus of my lab as we have been investigating the mechanisms of tracer uptake in tumors as well as evaluating the potentials for clinical utility of these tracers. My lab has also been developing novel reporter systems to study biology events associated with stem cell-based repair and regeneration in vivo.

Awards and Honors

1999 “Image of the Month”, SNIDD (before merged into Academy of Molecular Imaging)
2000 “Image of the Year”, Society of Nuclear Medicine
2009 “Teacher of the Year” for teaching (residents) Radiological Physics, UHCMC


H Guo, X Lu, J Molter, Y Hu, E Barnes, H Vogel, Z Lee, G Luo, B Wang, “a-fetoprotein-Thymidine Kinase-Luciferase Knockin Mice: A Novel Model for Dual Modality Longitudinal Imaging of Tumorigenesis in Liver”, Journal of Hepatology, (2011), doi:10.1016/j.jhep.2010.10.020

Y Kuang, N Salem, H Tian, JA Kolthammer, D Corn, C Wu, F Wang, Y Wang, Z Lee, “Imaging Lipid Synthesis in Hepatocellular Carcinoma with [Methyl-11C]Choline Correlated with Metabolites Study in vivo”, Journal of Nuclear Medicine, 52(1):98-106, 2011. (PMID: 21149484)

N Salem, Y Kuang, D Corn, B Erokwu, JA. Kolthammer, H Tian, C Wu, F Wang, Y Wang, Z Lee, “[(Methyl)1-11C]-Acetate Metabolism in Hepatocellular Carcinoma”, Molecular Imaging and Biology, 13:140-151, 2011 (PMID: 20401538)

Caimi PF, Reese J, Lee Z, Lazarus HM. Emerging therapeutic approaches for multipotent mesenchymal stromal cells. Curr Opin Hematol 17:505-513, 2010. PMID: 20729733

Ziady AG, Kotlarchyk M, Bryant L, McShane M, Lee Z. Bioluminescent imaging of reporter gene expression in the lungs of wildtype and model mice following the administration of PEG-stabilized DNA nanoparticles. Microsc Res Tech 73:918-928, 2010. PMID: 20306536

Salem N, Balkman JD, Wang J, Wilson DL, Lee Z, King CL, Basilion JP. In vivo imaging of schistosomes to assess disease burden using Positron Emission Tomography (PET). PLoS Negl Trop Dis 4:e827, 2010. PMID: 20877718

F Wang, Y Kuang, N Salem, P Anderson, Z. Lee, “Cross-species hybridization of woodchuck hepatitis virus-induced woodchuck hepatocellular carcinoma using human, rat and mouse oligonucleotide microarrays”, Journal of Gastroenterology and Hepatology, 24(4):605-17, 2009 (PMID: 19175833)

LaManna JC, Salem N, Puchowicz M, Erokwu B, Koppaka S, Flask C, Lee Z, “Ketones suppress brain glucose consumption”, Adv Exp Med Biol., 645:301-6, 2009

Wang F, Dennis JE, Awadallah A, Solchaga LA, Molter J, Kuang Y, Salem N, Lin Y, Tian H, Kolthammer JA, Kim Y, Love ZB, Gerson SL, Lee Z. Transcriptional profiling of human mesenchymal stem cells transduced with reporter genes for imaging. Physiol Genomics 37:23-34, 2009. PMCID: PMC2661103

H Tian, Z. Lee, “Radiosynthesis of 8-Fluoro-3-4-[18F]-Fluorophenyl-3,4-Dihydro-1-Isoquinolinamine ([18F]-FFDI), a Potential PET Radiotracer for the Inducible Nitric Oxide Synthase”, Current Radiopharmaceuticals, 1:49-53, 2008

Tang Z, Du R, Jiang S, Wu C, Barkauskas DS, Richey J, Molter J, Lam M, Flask C, Gerson S, Dowlati A, Liu L, Lee Z, Halmos B, Wang Y, Kern JA, Ma PC. Dual MET-EGFR combinatorial inhibition against T790M-EGFR-mediated erlotinib-resistant lung cancer. Br J Cancer 99:911-922, 2008. PMCID: PMC2538758

Salem N, Maclennan GT, Kuang Y, Anderson PW, Schomisch SJ, Tochkov IA, Tennant BC, Lee Z. Quantitative evaluation of 2-deoxy-2[F-18]fluoro-D-glucose-positron emission tomography imaging on the woodchuck model of hepatocellular carcinoma with histological correlation. Mol Imaging Biol 9:135-143, 2007. PMID: 17308952

Wang X, Yin L, Rao P, Stein R, Harsch KM, Lee Z, Heston WD. Targeted treatment of prostate cancer. J Cell Biochem 102:571-579, 2007. PMID: 17685433

Love Z, Wang F, Dennis J, Awadallah A, Salem N, Lin Y, Weisenberger A, Majewski S, Gerson S, Lee Z. Imaging of mesenchymal stem cell transplant by bioluminescence and PET. J Nucl Med 48:2011-2020, 2007. PMID: 18006616

H. Tian, Z. Lee, “Synthesis of [F-18]-labeled Cyclooxygenase-2 (COX-2) Inhibitor as a Potential PET Imaging Agent”, Journal of Labeled Compounds and Radiopharmaceuticals, 49:583-593, 2006

Lee Z, Sodee DB, Resnick M, Maclennan GT. Multimodal and three-dimensional imaging of prostate cancer. Comput Med Imaging Graph 29:477-486, 2005. PMID: 15893911

Z. Lee, MS Berridge, “PET imaging-based evaluation of aerosol drugs and their delivery devices: nasal and pulmonary studies”, IEEE Trans. Med. Imaging, Vol.21, No. 10, p.1324-1331, 2002


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(216) 844-7920
(216) 844-3106
Mailing Address
Bolwell S108, Radiology, University Hospitals Case Medical Center
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