Secondary Appointments

  • Professor, Department of Biomedical Engineering
  • Professor, General Medical Sciences - Oncology


  • Ph.D. Biomedical Engineering, Case Western Reserve University
  • B.S. Biomedical Engineering, Case Western Reserve University

Research Summary

Our laboratory for Image Guided Therapeutics has been working in the area of image-guided drug delivery since its inception in 2003 and our efforts have resulted in several techniques for noninvasive characterization and modulation of drug delivery on a broad scale – from in situ forming implants to multifunctional nanoparticles. We currently have two NIH-funded collaborative projects supporting our efforts. The first focuses on exploring the use of ultrasound to develop a comprehensive image-guidance approach for the development and application of in situ forming implants for intratumoral chemotherapy delivery. The second project engineers ultrasound contrast agents on the nano-scale for ultrasound-guided delivery of a bioactive agent for cancer hyperthermia treatment. Our laboratory is also involved in many other applications of imaging to drug delivery, such as external modulation of drug delivery system behavior in vivo or concurrent tumor detection and therapy hold great promise and could lead to considerable advancements in the field. In all of our projects including the current we continue to work alongside clinical interventional radiologists to develop approaches with high clinical relevance and potential for eventual translation, and we have continued to engage engineering collaborators to continue development of new cutting edge technologies. Our research is supported by the National Cancer Institute and National Institute for Biomedical Imaging and Bioengineering.

Selected Publications

  • Zhou H, Hernandez C, Goss M, Gawlik A, Exner AA.  Biomedical Imaging in Implantable Drug Delivery Systems. Current Drug Targets invited mini-review for special focus issue on Image-Guided Drug Delivery.  In Press. Published online November 22, 2014. PMID: 25418857 
  • Perera R, Hernandez C, Zhou H, Kota P, Burke A, Exner AA. Ultrasound Imaging Beyond the Vasculature with New Generation Contrast Agents. WIRES Nanomedicine and Nanobiotechnology, Invited Focus Article. 2015; 7(4): 593–608., Published online January 8, 2015. PMID: 25580914
  • Wu H, Wilkins L, Ziats N, Haaga K, Exner AA.  Real-time Monitoring of Radiofrequency Ablation and Postablation Assessment: Accuracy of Contrast-enhanced US in Experimental Rat Liver Model. Radiology . 2014; 270(1):107-16. PMID: 23912621
  •  Perera R, Solorio L, Wu H, Gangolli M, Silverman E, Hernandez C,  Exner AA. Nanobubble ultrasound contrast agents for enhanced delivery of thermal sensitizer to tumors undergoing radiofrequency ablation; Pharmaceutical Research, Special issue on image-guided drug delivery. 2014 Jun; 31(6):1407-17. PMID: 23943542
  • Wu H, Rognin NG; Krupka TM; Yoshiara H; Guenette G; Sanders C; Kamiyama N, Exner AA. Acoustic characterization and pharmacokinetic analyses of new nanobubble ultrasound contrast agents. Ultrasound in Medicine and Biology. Ultrasound Med Biol. 2013; 39(11):2137-46. PMID: 23932272
  • Solorio L, Exner AA. Research Spotlight: Applications of ultrasound for image-guided drug delivery in cancer chemotherapy. Ther Deliv. 2013 Jul;4(7):785-9. PMID: 23883123
  • Perera R, Patel R, Wu H, Gangolli M, Traughber B, Oleinick N, Exner AA. Preclinical Evaluation of Radiosensitizing Activity of Pluronic Block Copolymers.  International J of Radiation Biology. Int J Radiat Biol. 2013; 89(10):801-12. PMID: 23631609 *Article featured on

Mailing Address
11100 Euclid Avenue
Department of Radiology
Wearn Building, Room 353
Cleveland, OH 44106-5056

Exner Lab Website

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