- Associate Professor, Department of Biomedical Engineering
- Associate Professor, General Medical Sciences - Oncology
- Ph.D. Biomedical Engineering, Case Western Reserve University
- B.S. Biomedical Engineering, Case Western Reserve University
Our laboratory for Image Guided Therapeutics has been working in the area of image-guided drug delivery since its inception in 2003 and our efforts have resulted in several techniques for noninvasive characterization and modulation of drug delivery on a broad scale – from in situ forming implants to multifunctional nanoparticles. We currently have two NIH-funded collaborative projects supporting our efforts. The first focuses on exploring the use of ultrasound to develop a comprehensive image-guidance approach for the development and application of in situ forming implants for intratumoral chemotherapy delivery. The second project engineers ultrasound contrast agents on the nano-scale for ultrasound-guided delivery of a bioactive agent for cancer hyperthermia treatment. Our laboratory is also involved in many other applications of imaging to drug delivery, such as external modulation of drug delivery system behavior in vivo or concurrent tumor detection and therapy hold great promise and could lead to considerable advancements in the field. In all of our projects including the current we continue to work alongside clinical interventional radiologists to develop approaches with high clinical relevance and potential for eventual translation, and we have continued to engage engineering collaborators to continue development of new cutting edge technologies. Our research is supported by the National Cancer Institute and National Institute for Biomedical Imaging and Bioengineering.
- Patel RB, Solorio L, Wu H, Krupka TM, Exner AA, Effect of injection site on in situ implant formation and drug release in vivo. J Controlled Release. EpubAug 20, 2010. PMID: 20728486.
- Solorio L, Patel R, Babin B, Mach J, Azar N, Exner AA. Noninvasive characterization of in situ forming implants using ultrasound. J Controlled Release. 2010; 143(2):183-90. Epub 2010 Jan 11. PMID: 20060859
- Krupka TM, Solorio L, Wilson R, Wu H, Azar N, Exner AA. Formulation and Characterization of Echogenic Perfluorocarbon Nanobubbles. Mol Pharm.2010; 7(1):49-59. PMID: 19957968
- Wu H, Exner AA, Krupka TM, Weinberg BD, Patel R, Haaga JR. Radiofrequency ablation: post-ablation assessment using CT perfusion with pharmacological modulation in a rat subcutaneous tumor model. Acad Radiol. 2009; 16(3):321-31. PMID: 19201361
- Krupka TM, Dremann D, Exner AA. Time and dose dependence of Pluronic bioactivity in hyperthermia-induced tumor cell death. Exp Biol Med. 2009; 234(1):95-104. PMID: 18997100
- Exner AA and Saidel G. Drug Eluting Polymeric Implants for Cancer Therapy. Expert Opinion on Drug Delivery. Invited review article. 2008; 5(7):775-788. PMID: 18590462
11100 Euclid Avenue
Department of Radiology
Wearn Building, Room 353
Cleveland, OH 44106-5056
Exner Lab Website